Computational Chemist

Computational Chemist

Hours: 37.5 hours per week, Monday – Friday. Flexible working hours.

Ref No: HRJOB11154

Business Unit: Almac Discovery

Open To: Internal & External Candidates

Location: Greater Manchester or Belfast. Preference will be asked at application.

Almac Discovery

Our vision is to be widely recognised and acknowledged within the global biopharmaceutical community as an industry-leading discoverer and developer of innovative, first-in-class, drug molecules.

By fully utilising the expertise and knowledge of our team to address the significant hurdles inherent in drug discovery, we are driven to make fundamental contributions to the development and advancement of new medicines that address unmet medical needs across a range of therapeutic indications.

The Role

The post holder will have the opportunity to develop and apply advanced computational techniques to accelerate innovative drug discovery programmes, spanning various modalities including induced proximity, covalency, and antibody drug conjugates.

Working across project teams, the role will involve the use of cutting-edge computational methods (including AI/ML) such as structure/ligand-based design, predictive modelling, virtual screening and ADMET prediction to effectively advance programs using creative solutions and insights.

The post will require a dynamic self-starter with an eagerness to learn who will be an integral member of the AD Chemistry and Informatics teams. They must exhibit excellent people skills and the ambition to thrive within a highly interactive, fast-paced team.

This is an exciting opportunity to play a central role in the further development of Almac Discovery as an innovative and successful biotechnology company. Preference will be given to a motivated individual with a high level of scientific commitment and a strong work ethic, who thrives in a highly collaborative environment.

Travel Requirement: As part of this dynamic role, you will be expected to travel across all Almac Discovery locations, including Belfast, Edinburgh, and Manchester. Flexibility and willingness to travel are essential to support the needs of the business. The post holder must be able to undertake travel in line with business requirements.

Essential Criteria

· BSc / MSc in Chemoinformatics, computational chemistry or structural biology

· Relevant work experience in either an academic or industrial scientific setting

· Experience of HPC infrastructure / Linux systems

· Able to implement key R and / or Python packages.

· Experience with AI/machine learning algorithms.

· Experience using CADD software e.g. MOE or Schrodinger.

Desirable Criteria

(The following criterion may be applied if a large pool of applicants exists)

· PhD in Chemoinformatics, computational chemistry or structural biology

· Drug Discovery expertise in an industrial scientific setting.

· Experience working with next-generation structural design tools such as AlphaFold2.

· Experience developing databases (e.g. SQL)

Application Closing Date: Tuesday 2nd December 2025 at 5pm

RECRUITMENT AGENCIES PLEASE NOTE: Almac will only accept applications from agencies/business partners that have been invited to work on this role by our Talent Acquisition team. Speculative candidate CVs received or submitted directly to Hiring Managers will be considered unsolicited, and no fee will be payable. Thank you for your cooperation.